CALYCULIN A, DISCODERMIA CALYX
Calyculin A
CAS: 101932-71-2
Molecular Formula: C50H81N4O15P
CALYCULIN A, DISCODERMIA CALYX - Names and Identifiers
CALYCULIN A, DISCODERMIA CALYX - Physico-chemical Properties
| Molecular Formula | C50H81N4O15P |
| Molar Mass | 1009.17 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Melting Point | 247-249° |
| Specific Rotation(α) | D -60° (c = 0.1 in ethanol) |
| Water Solubility | Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water. |
| Solubility | DMSO: soluble |
| Appearance | solid |
| Color | white |
| Merck | 13,1731 |
| BRN | 4903216 |
| pKa | 1.81±0.10(Predicted) |
| Storage Condition | -20°C |
| Use | Calculin A is A potent, cell-permeable inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) with IC50 values of 2 nM and 0.5-1 nM, respectively. |
| In vitro study | Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner up to 10 nM in MG63 cells. Cell Cytotoxicity Assay Cell Line: Human osteosarcoma MG63 cells Concentration: 0, 1, 2, 5, 10 nM Incubation Time: 24 hours Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures. |
CALYCULIN A, DISCODERMIA CALYX - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R38 - Irritating to the skin |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
CALYCULIN A, DISCODERMIA CALYX - Reference Information
| biological activity | Calyculin A ((-)-Calyculin A) is an effective and permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor, with IC50 values of 2 nM and 0.5-1 nM respectively. |
| target | IC50: 2 nM (PP1); 0.5-1 nM (PP2A) |
| in vitro research | Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner up to 10 nM in MG63 cells. Cell Cytotoxicity Assay Cell Line: Human osteosarcoma MG63 cells Concentration: 0, 1, 2, 5, 10 nM Incubation Time: 24 hours Result: treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures. |
| Cell Line: | Human osteosarcoma MG63 cells |
| Concentration: | 0, 1, 2, 5, 10 nM |
| Incubation Time: | 24 hours |
| Result: | Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures. |
Last Update：2024-04-09 21:49:45
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View History
CALYCULIN A, DISCODERMIA CALYX
甲基-六聚乙二醇-(CH2)8-膦酸乙酯
3-间溴苯基-4-溴-5-甲酸甲酯-1H-吡唑
Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-
2-Butanamine, 1,1,1-trifluoro-3-methyl-, hydrochloride (1:1)
22-hydroxycholest-4-en-3-one
1-萘基溴化镁, 0.5M METHF 溶液
3-PHENYLPENTANOIC ACID
3-Pyrazol-1-ylmethyl-piperidine
甲基-六聚乙二醇-(CH2)8-膦酸乙酯
3-间溴苯基-4-溴-5-甲酸甲酯-1H-吡唑
Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-
2-Butanamine, 1,1,1-trifluoro-3-methyl-, hydrochloride (1:1)
22-hydroxycholest-4-en-3-one
1-萘基溴化镁, 0.5M METHF 溶液
3-PHENYLPENTANOIC ACID
3-Pyrazol-1-ylmethyl-piperidine